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Associations of cardiac function of patients with dilated cardiomyopathy and chronic heart failure with kidney injury molecule-1 and renal and vascular endothelial functions |
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| รหัสดีโอไอ | |
| Creator | Jie Chen |
| Title | Associations of cardiac function of patients with dilated cardiomyopathy and chronic heart failure with kidney injury molecule-1 and renal and vascular endothelial functions |
| Contributor | Jue Zhao, Xue Zhang |
| Publisher | Maejo University |
| Publication Year | 2569 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 20 |
| Journal No. | 1 |
| Page no. | 16 |
| Keyword | cardiac function, chronic heart failure, dilated cardiomyopathy, kidney injury molecule-1, renal function, vascular endothelial function |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | The associations of cardiac function of patients with dilated cardiomyopathy (DCM) and chronic heart failure (CHF) with kidney injury molecule-1 (KIM-1) and renal and vascular endothelial functions were explored. The subjects (80 in total) were recruited from patients undergoing treatment between June 2020 and July 2022. A retrospective analysis was implemented on their clinical data, and grade-I group (n=16), grade-II group (n=36) and grade-III group (n=28) were set up in accordance with New York Heart Association classification standards for cardiac function. The levels of endothelin-1, thromboxane B2, serum creatinine, blood urea nitrogen, cystatin C, glomerular filtration rate and KIM-1 were higher in grade-II and grade-III groups than in the grade-I group and also higher in the gradeIII group than in the grade-II group (P<0.05). This study comprehensively analyses the association of KIM-1, vascular endothelial function and renal function with crdiac functional status in DCM-related CHF. The findings suggest that these biomarkers may serve as sensitive indicators for early detection of cardiac dysfunction and guide timely clinical interventions. |
