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Bioinformatic investigation of dietary natural compounds for prevention of onset of pre-symptomatic Alzheimers disease by inhibiting caspase-1 |
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| รหัสดีโอไอ | |
| Creator | Song Ja Kim |
| Title | Bioinformatic investigation of dietary natural compounds for prevention of onset of pre-symptomatic Alzheimers disease by inhibiting caspase-1 |
| Contributor | Fahad Hassan Shah, Young Seok Eom |
| Publisher | Maejo University |
| Publication Year | 2565 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 16 |
| Journal No. | 3 |
| Page no. | 179 |
| Keyword | pre-symptomatic neurodegeneration, caspase-1, dietary natural compounds, Alzheimers disease, molecular docking |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | Caspase-1 (CASP1) is a cysteine protease which is an integral part of the inflammasome and is involved in the proteolytic cleavage of inflammatory cytokines and regulating cell apoptosis. Inhibition of CASP1 deters neurodegeneration and can delay the onset of pre-symptomatic Alzheimers disease (AD). Various clinical trials have highlighted the significance of dietary natural compounds (DNCs) in the prevention of AD. However, these trials focused on exploring the efficacy of these compounds in already established disease pathology. This research article evaluates the efficacy of DNCs against CASP1 in the prevention of pre-symptomatic AD disease. To determine the interactive potential of DNCs, an elaborate literature review was performed to look for those compounds involved in the prevention of AD. Twenty-six compounds were obtained and these are commonly found in fruits and vegetables. These compounds were further analysed with iGEMDOCK to determine their affinity with the reported active site of CASP1. Among 26 compounds, apigenin, chlorogenic acid, caffeic acid, epigallocatechin gallate, quercetin, petunidin and syringic acid successfully interacted with the reported active site of CASP1. From this study, we provide an insilico justification that these DNCs may prevent the onset of pre-symptomatic AD and rescue neuronal integrity and synaptic plasticity from CASP1 |
