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Efficiency evaluation of topical emulsion of Croton thorelii Gagnep. extract and its related properties |
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| รหัสดีโอไอ | |
| Creator | Ampa Jimtaisong |
| Title | Efficiency evaluation of topical emulsion of Croton thorelii Gagnep. extract and its related properties |
| Contributor | Nisakorn Saewan |
| Publisher | Maejo University |
| Publication Year | 2565 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 16 |
| Journal No. | 2 |
| Page no. | 124 |
| Keyword | Croton thorelii Gagnep. Extract, moisturising cream, skin-lightening cream |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | The leaves of Croton thorelii Gagnep. were simply extracted by maceration in propylene glycol (PG), 95% ethanol and water using a sample-to-solvent ratio of 1:6 w/w for 4 hr at 50C. The extract prepared using PG exhibits relatively higher biological activities than those using ethanol and water. It has a total phenolic content of 3.92 0.02 mg gallic acid eq./mL and the extract exhibits antioxidant activities, i.e. reducing power (103.90 0.41 mM ascorbic acid eq./mL), DPPH radical scavenging activity (81.11 8.08%), and anti-tyrosinase activity (30.30 2.50%). A topical emulsion was developed with 7% C. thorelii Gagnep. PG extract. The emulsion cream was classified as non-irritant after being clinically tested in 20 human volunteers. The efficacy test was performed by applying the product twice daily on the forearm for four weeks. It was found that the C. thorelii Gagnep. cream continually increased the skin moisture content significantly (p<0.05) about 2 times higher than that by the cream base. The skin melanin content also decreased significantly (p<0.05) and the decrease is higher (5.80%) than that by the cream base (3.80%). Additionally, the skin showed an increase in smoothness significantly (p<0.05) by the cream with C. thorelii Gagnep. extract (14.89%), which is two times higher than that by the cream base. The cream with C. thorelii Gagnep. also significantly decreased (p<0.05) the skin roughness by 11.76%. The results obtained indicate that C. thorelii Gagnep. can potentially be used as a skin-lightening and anti-aging ingredient in topical cosmetic preparations. |
