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Anti-proliferative and apoptotic effects of ethanolic extracts of the seaweed Caulerpa lentillifera against human glioblastoma cells |
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| รหัสดีโอไอ | |
| Creator | Tanapan Siangcham |
| Title | Anti-proliferative and apoptotic effects of ethanolic extracts of the seaweed Caulerpa lentillifera against human glioblastoma cells |
| Contributor | Kant Sangpairoj, Pornpun Vivithanaporn |
| Publisher | The Pharmacological and Therapeutic Society of Thailand |
| Publication Year | 2565 |
| Journal Title | Journal of Basic and Applied Pharmacology |
| Journal Vol. | 2 |
| Journal No. | 1 |
| Page no. | O37-42 |
| Keyword | Caulerpa lentillifera, seaweed, glioblastoma, proliferation, apoptosis |
| URL Website | https://li01.tci-thaijo.org/index.php/JBAP |
| Website title | เว็บไซต์คลังข้อมูล |
| ISSN | 2774-0854 (Online) |
| Abstract | Caulerpa lentillifera (CL), or sea grapes, is a widely consumed as food in Asia. Our previous study showed the anti-proliferative and apoptosis effects of the hexane extract of this seaweed. We investigated the effects of the ethanolic extract of this seaweed (CLET) on the in vitro proliferation and apoptotic cell death in A172 human glioblastoma cells using MTT, CFSE, and Annexin V-FITC assays. CLET at 500 µg/ml reduced A172 cell viability by inducing apoptotic cell death, while lower concentrations of CLET reduced proliferation of A172 cells. The present study suggests that CLET could inhibit proliferation and promote apoptotic cell death in human GBM cells, suggesting its potential to be used as an alternative treatment for glioblastoma. |
