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Cadmium (Cd)-concentration and histopathological changesandmetallothionien expression in the kidney of wildgreat bandicoots residing in a Cd-intoxicated area in Thailand |
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| รหัสดีโอไอ | |
| Creator | Wiphawi Hipkaeo |
| Title | Cadmium (Cd)-concentration and histopathological changesandmetallothionien expression in the kidney of wildgreat bandicoots residing in a Cd-intoxicated area in Thailand |
| Contributor | Kedsarin Siriked, NatthiyaSakulsak,Wisa Supanpaiboon, Supaporn Cheunchoojit, Hisatake Kondo |
| Publisher | Research and Technology Transfer Affairs Division.Khon Kaen University. |
| Publication Year | 2560 |
| Journal Title | Asia-Pacific Journal of Science and Technology (APST) |
| Journal Vol. | 22 |
| Journal No. | 1 |
| Page no. | 1-9 |
| Keyword | cadmium, wild great bandicoot, kidney,light microscopy, metallothionien expression, weight-size subgrouping |
| URL Website | https://tci-thaijo.org/index.php/APST/index |
| Website title | https://tci-thaijo.org/index.php/APST/article/view/84854 |
| ISSN | 2539-6293 |
| Abstract | The cadimium (Cd)-concentration and gene expression for metallothionien, an intrinsic Cd?detoxifying protein, as well as its histopathology were examined in kidneys of wild greater bandicoot rats from Cd-contaminated and uncontaminated areas in Thailand. The Cd-concentration was greater in higher body-weight and sized from both the contaminated and uncontaminated areas. The Cd-concentration in large-sized animals from the contaminated area was the highest among all the specimens, while that in medium-sized animals from the contaminated area was higher than that in large-sized ones from the uncontaminated area. No significant differences in the Cd?concentration in the specimen's kidneys was noted between small-sized animals from the contaminated and uncontaminated areas. Histopathological changes such as necrosis, inflammatory cell infiltration and fibrosis, were more severe in the kidneys of animals with larger body sizes from the contaminated area. No significant differences in the expression of the gene for metallothionien were noted between kidneys of the animals from the contaminated and uncontaminated areas. |
