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The Prediction of Low Four-Hour Parathyroid Hormone Level After Total Thyroidectomy on Hypocalcemia |
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| รหัสดีโอไอ | |
| Creator | Watsaphon Tangkullayanone |
| Title | The Prediction of Low Four-Hour Parathyroid Hormone Level After Total Thyroidectomy on Hypocalcemia |
| Contributor | Wilairat Prasert, Sasithorn Sujarittanakarn |
| Publisher | Thammasat Printing House |
| Publication Year | 2564 |
| Journal Title | Asian Medical Journal and Alternative Medicine |
| Journal Vol. | 21 |
| Journal No. | 2 |
| Page no. | 119 |
| Keyword | Postoperative hypoparathyroid, Postoperative hypocalcemia |
| URL Website | http://asianmedjam.com/ |
| Website title | asianmedjam |
| ISSN | 2730-3578 |
| Abstract | Objective: The purpose of the study is to study parathyroid hormone (PTH) level in prediction of early post-thyroidectomy hypocalcemia and long term hypoparathyroidism or hypocalcemia outcome six months after surgery.Method:Patients who underwent total thyroidectomy or completion thyroidectomy procedure from July 2015 to July 2018 were studied. Corrected serum calcium and PTH levels were measured 4-hour after thyroidectomy and monitored from 24 to 48 hours. The levels of PTH and calcium were graded as normal or low levels. These data were analyzed using validation tools; sensitivity, specificity, positive predictive value, negative predictive value, and accuracy.Result: Out of a total of 66 patients, 24 cases were detected with low PTH levels after total thyroidectomy. The sensitivity and specificity of low PTH levels in the prediction of hypocalcemia were 45% and 79%, respectively, with a 79% positive predictive value and 58% accuracy. Prediction of permanent hypoparathyroidism after total thyroidectomy was with 53% sensitivity, 81% specificity and 66% accuracy.Conclusion: The low PTH levels may be an indicator of hypocalcemia after total thyroidectomy, in which the evidence shows high specificity and positive predictive value. Therefore, if hypoparathy-roidism is detected after total thyroidectomy, hypocalcemia is high likely, so calcium or vitamin D replacement should be provided to prevent severe hypocalcemia. |
