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The study of prevalence and associated factors for long COVID among patients during Delta- and Omicron-dominated waves at Thammasat University Hospital |
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| รหัสดีโอไอ | |
| Title | The study of prevalence and associated factors for long COVID among patients during Delta- and Omicron-dominated waves at Thammasat University Hospital |
| Creator | Chonlawat Chaichan |
| Contributor | Paskorn Sritipsukho, Advisor |
| Publisher | Thammasat University |
| Publication Year | 2568 |
| Keyword | Long COVID, Delta, Omicron, Thailand, Prevalence, Associated factor |
| Abstract | Long COVID is characterized by the persistence or emergence of symptoms beyond threemonths after an acute COVID-19 infection. This study aimed to assess the point prevalence andassociated risk factors for long COVID during the Delta and Omicron variant-dominant periods inThailand, with evaluations conducted at 3 and 6 months post-infection. By investigating these factors,the research provides a comprehensive understanding of long COVID's prevalence and risk factors acrossdifferent epidemic phases.The COVID-19 cohort from Thammasat University Hospital (TUH) and Thammasat FieldHospital (TFH) was followed using a negative case-control design during the Delta and Omicron variant-dominant waves. Telephone interviews were conducted to assess long COVID symptoms at 3 monthsfor 1,128 Delta-infected patients and 1,388 Omicron-infected patients, and at 6 months for 961 Delta-infected and 917 Omicron-infected patients. Clinical characteristics of all participants were extractedfrom the hospital's database.The point prevalence of long COVID in the Delta wave was 37.15% at 3 months and32.57% at 6 months, compared to 52.59% at 3 months and 28.57% at 6 months during the Omicron wave.Common risk factors across both the Delta and Omicron waves included female sex and severe-to-criticalacute illness. In the Delta wave, being female was associated with an adjusted odds ratio (AOR) of 3.03[95% confidence interval (CI): 2.30–3.99] at 3 months and 2.84 [95% CI: 2.08–3.86] at 6 months.Similarly, during the Omicron wave, the AOR for females was 2.05 [95% CI: 1.62–2.60] at 3 months and 2.41 [95% CI: 1.74–3.35] at 6 months. Severe-to-critical acute illness was also a significant predictor,with AORs of 10.8 [95% CI: 4.24–27.51] at 3 months and 5.50 [95% CI: 2.06–14.68] at 6 months duringthe Delta wave. In the Omicron wave, severe-to-critical illness was associated with an AOR of 4.35 [95%CI: 1.56–12.15] at 3 months and 8.90 [95% CI: 1.24–58.86] at 6 months.In conclusion, long COVID prevalence remained substantial following the Delta andOmicron variant-dominant periods. The shared risk factors at both 3 and 6 months in both waves includedfemale sex and severe-to-critical acute illness. |
