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Therapeutic effects of doxycycline combined with azithromycin and levofloxacin on tsutsugamushi disease and its influence on neutrophil count and lymphocyte count |
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| รหัสดีโอไอ | |
| Creator | Jun Qian |
| Title | Therapeutic effects of doxycycline combined with azithromycin and levofloxacin on tsutsugamushi disease and its influence on neutrophil count and lymphocyte count |
| Contributor | Xiaohui Cui, Linling Ju, Haiyan Wang, Lin Chen |
| Publisher | Maejo University |
| Publication Year | 2566 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 17 |
| Journal No. | 3 |
| Page no. | 279 |
| Keyword | tsutsugamushi disease, scrub typhus, doxycycline, levofloxacin, azithromycin, neutrophil, lymphocyte |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | To assess the therapeutic effects of doxycycline combined with azithromycin and levofloxacin on tsutsugamushi disease (TD) and its influence on neutrophil count (NE) and lymphocyte count (LY), a retrospective analysis was performed on the clinical data of 108 patients with TD hospitalised from June 2019 to June 2021. The patients were divided into control group (n=51) receiving doxycycline and observation group (n=57) receiving doxycycline, azithromycin and levofloxacin. Their recovery indices, serum indicators [neutrophil count (NE), lymphocyte count (LY), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), D-dimer (D-D) and procalcitonin (PCT)], disease severity [acute physiology and chronic health evaluation (APACHE II) scores], adverse reactions and prognoses (recurrence rate and mortality rate) were compared. Results show that the observation group took a shorter time than the control group in fever abatement, disappearance of other clinical symptoms and signs, and recovery of laboratory indicators to a normal level (P<0.05). Its neutrophil count, NLR, CRP, D-D, PCT and APACHE II score was also lower while LY was higher than the control group (P<0.05). No mortality occurred in the two groups. In terms of adverse reactions, the two groups had similar incidence and recurrence rates (P>0.05). |
