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Correlations of serum D-dimer, N-terminal prohormone of brain natriuretic peptide and inflammatory cytokine levels with prognosis of children with severe pneumonia |
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| รหัสดีโอไอ | |
| Creator | Ye Tian |
| Title | Correlations of serum D-dimer, N-terminal prohormone of brain natriuretic peptide and inflammatory cytokine levels with prognosis of children with severe pneumonia |
| Contributor | Xiaohua Shi, Li Qian |
| Publisher | Maejo University |
| Publication Year | 2566 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 17 |
| Journal No. | 2 |
| Page no. | 113 |
| Keyword | prognosis, severe pneumonia, inflammatory cytokine, D-dimer, N-terminal prohormone of brain natriuretic peptide |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | The roles of serum D-dimer, N-terminal prohormone of brain natriuretic peptide (NT-ProBNP) and inflammatory cytokines in children with severe pneumonia remain unclear. We aim to explore the correlations of serum D-dimer, NT-ProBNP and inflammatory cytokines with the prognosis of children with severe pneumonia. Eighty-six children treated from June 2018 to March 2019 were divided into the surviving group (n=51) and the fatal group (n=35). Thirty healthy children were enrolled as a control group. The serum D-dimer, NT-ProBNP, tumour necrosis factor-alpha (TNF-), interleukin-6 (IL-6) and APACHE II scores decreased in the surviving group but increased in the fatal group (P<0.05). They were significantly higher in the latter group than those in the former group. The levels of serum D-dimer and NT-ProBNP positively correlated with TNF-, IL-6 and APACHE II score (P<0.05). The areas under the receiver operator characteristic curves of serum D-dimer, NT-ProBNP, TNF- and IL-6 for prediction were 0.846, 0.792, 0.681 and 0.686 respectively (P<0.05), which peaked at 0.973 in the case of combined prediction using the four indicators (P<0.001), suggesting a higher diagnostic value. D-dimer, NT-ProBNP and inflammatory cytokines (TNF- and IL-6) are potential indicators for evaluating the severity and prognosis of pneumonia in children, and the combined detection provides references for clinical assessment and prognostic prediction. |
