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Assessment of skin allergic and irritant reactions of Delonix regia flower extract and the finished cosmetic products |
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| รหัสดีโอไอ | |
| Creator | Worapapar Treesuppharat |
| Title | Assessment of skin allergic and irritant reactions of Delonix regia flower extract and the finished cosmetic products |
| Contributor | Wiratchanee Mahavorasirikul, Sumet Kongkiatpaiboon, Panlop Chakkavittumrong |
| Publisher | The Pharmacological and Therapeutic Society of Thailand |
| Publication Year | 2565 |
| Journal Title | Journal of Basic and Applied Pharmacology |
| Journal Vol. | 2 |
| Journal No. | 1 |
| Page no. | O1-10 |
| Keyword | Delonix regia, human patch test, skin irritant, skin allergy, cosmetic ingredient |
| URL Website | https://li01.tci-thaijo.org/index.php/JBAP |
| Website title | เว็บไซต์คลังข้อมูล |
| ISSN | 2774-0854 (Online) |
| Abstract | Delonix regia (Hook.) Raf. is an ornamental tree with attractive flowers, and it is a symbolic tree of Thammasat University, Thailand. Its flowers contain rutin as major component with pronounced antioxidative properties. Many studies showed the cosmeceutical potential of D. regia flower (DRF) extract including antioxidant, antimicrobial, and photoprotective activities. In the course of utilizing DRF extract as a cosmetic ingredient, the evaluation of the skin allergic and irritant reactions of the DRF extract and the finished cosmetic products in healthy subjects was studied. Skin compatibility of DRF extract and the finished cosmetic products was evaluated using human single application closed patch epicutaneous test. The results showed that DRF extract up to a concentration of 4% w/w did not cause any skin irritation. Weak allergic reaction was observed with 4% w/w extract in 1 of the 29 subject. Body lotion and hand cream containing 0.3% w/w DRF did not cause any allergic reaction. Liquid soap containing 0.05% w/w DRF extract caused slight erythema (grade +) in 2 subjects. Therefore, DRF extract could be used safely as topical cosmetics up to the concentration of 4% w/w. |
