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Effect of Emulgel containing Langkasuka Oil versus Diclofenac Gel for Improving Physical Function in Patients with Knee Osteoarthritis: A randomized controlled trial |
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| รหัสดีโอไอ | |
| Creator | Kulkamol Vannasri |
| Title | Effect of Emulgel containing Langkasuka Oil versus Diclofenac Gel for Improving Physical Function in Patients with Knee Osteoarthritis: A randomized controlled trial |
| Contributor | Suwanna Maenpuen, Prakairat Tunit |
| Publisher | Phetchaburi Rajabhat University |
| Publication Year | 2569 |
| Journal Title | Interdisciplinary Research Review (IRR) |
| Journal Vol. | 21 |
| Journal No. | 2 |
| Page no. | 27-36 |
| Keyword | Knee osteoarthritis, Emulgel, Langkasuka Oil, Physical function, Diclofenac gel |
| URL Website | https://ph02.tci-thaijo.org/index.php/jtir |
| Website title | Interdisciplinary Research Review (IRR) |
| ISSN | 2697-536X |
| Abstract | Knee osteoarthritis (KOA) is characterized by a progressive decline in physical functioning. Emulgel containing Langkasuka oil (ELO) represents a newly developed formulation incorporating Langkasuka oil (LO) as an active constituent. This study aimed to evaluate the impact of ELO on lower limb function and mobility, as assessed by the Timed Up and Go (TUG) test and 30-Second Chair Stand (30-CST) test. A randomized controlled trial was performed between July 2025 and February 2026. A total of 62 participants were randomly allocated into two groups of 31 each: an experimental group receiving topical ELO and a control group receiving topical diclofenac gel (DG). Both groups were instructed to apply the assigned substance to the knee area three times daily for a period of four weeks. Outcome measures were assessed at baseline, day 14, and day 28.Statistical analysis was performed using repeated measures ANOVA to assess within-group changes over time, and one-way ANOVA to examine between-group differences.The results of the ELO group showed a progressive decline in mean scores from 11.29±1.42 at baseline to 8.10±0.94 at Day 28, indicating a clinically significant transition from moderate fall risk to normal functional status. A comparable reduction was observed in the DG group, with mean scores decreasing from 11.26±1.55 at baseline to 8.06±1.12 at Day 28.Both the ELO and DG groups demonstrated statistically significant improvements in 30-CST performance over the 28-day intervention period (p<0.001), with mean scores increasing from 8.61±1.05 to 10.26±1.29 and from 8.65±0.98 to 10.13±1.26, respectively.In conclusion, ELO demonstrated physical performance improvements comparable to those observed with DG, suggesting its potential as an alternative topical therapeutic option for the management of KOA. |
