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Effects of oral vitamin C treatment on metabolism at rest and in response to an acute exercise in patients with poorly controlled type 2 diabetes mellitus |
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| รหัสดีโอไอ | |
| Creator | Chongchira Boonthongkaew |
| Title | Effects of oral vitamin C treatment on metabolism at rest and in response to an acute exercise in patients with poorly controlled type 2 diabetes mellitus |
| Contributor | Terdthai Tong-un, Yupaporn Kanpetta, Nisa Chaungchot, Ian Macdonald, Chanvit Leelayuwat, Naruemon Leelayuwat |
| Publisher | Faculty of Associated Medical Sciences, Khon Kaen University, Thailand |
| Publication Year | 2563 |
| Journal Title | Archives of Allied Health Sciences |
| Journal Vol. | 32 |
| Journal No. | 2 |
| Page no. | 36-50 |
| Keyword | Ascorbic acid, Hyperglycemia, Insulin resistance, Lipid oxidation, Physical activity |
| URL Website | https://he01.tci-thaijo.org/index.php/ams/about |
| Website title | Archives of Allied Health Sciences (Arch AHS) |
| ISSN | 2730-1990 |
| Abstract | Metabolic disturbances at rest and in responses to exercise are the hallmarks of type 2 diabetes mellitus (T2DM). Although vitamin C was shown to improve resting glycemia and lipid profile in patients with T2DM, a study investigating the effects of vitamin C treatment on the metabolic responses at rest and to low-intensity exercise in poorly controlled T2DM patients has not been conducted yet. This study aimed to investigate the effects of oral vitamin C treatment on metabolism at rest and in response to an acute exercise inpatients. Twenty T2DM patients were randomly participated in the following two six-week arms with a six-week washout period: either daily placebo or 1000mg vitamin C. On the first and last day of each session, they performed 20-min low-intensity cycling. Five-min expired gas was collected before starting and finishing the exercise. Immediately before and after the exercise, venous blood samples were collected. Vitamin C decreased resting cholesterol concentration compared with placebo treatment (p-value < 0.05) without any effect after the exercise. Post-vitamin C treatment, fat oxidation rate was higher during exercise than at baseline (p-value < 0.05). Resting total cholesterol/high-density lipoprotein-cholesterol and glucose concentrations in plasma at rest and after exercise were lower at post- compared with pre-vitamin C treatment (p-value <0.05). Additionally, pre- and post-treatment, rates of oxygen consumption and carbohydrate oxidation, and energy expenditure were higher during exercise than at baseline in both treatment arms (p-value <0.05). The findings suggest that daily treatment with 1000 mg of vitamin C for six weeks reduced the resting cholesterol concentration in patients with poorlyglycemic controlled T2DM. However, this effect was not observed immediately after exercise. Nonetheless, post-vitamin C treatment, fat utilization during exercise was higher than baseline. Besides, low-intensity exercise increased oxygen consumptionrate, carbohydrate oxidation rate, and energy expenditure, pre- and post- both treatment arms. |
