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Bioactivity of chitosan microparticles loaded with Apus bamboo (Gigantochloa apus) shoot extract: Emphasis on characterization and in vitro antibacterial properties for acne treatment. |
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| รหัสดีโอไอ | |
| Creator | Muflihatul Muniroh |
| Title | Bioactivity of chitosan microparticles loaded with Apus bamboo (Gigantochloa apus) shoot extract: Emphasis on characterization and in vitro antibacterial properties for acne treatment. |
| Contributor | Aqsa Aufa Syauqi Sadana, Sineba Nafti Rizkite Barly, Lugas Firdinand Hamdi, Nurul Azizah Dian Rahmawati, Araminta Vania Saraswati, A’liyatur Rosyidah |
| Publisher | Khon Kaen University, Thailand |
| Publication Year | 2568 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 30 |
| Journal No. | 5 |
| Page no. | 5 (10 pages) |
| Keyword | acne vulgaris, Apus bamboo shoots, chitosan, microparticles, spray gel |
| URL Website | https://apst.kku.ac.th/ |
| Website title | https://apst.kku.ac.th/bioactivity-of-chitosan-microparticles-loaded-with-apus-bamboo-gigantochloa-apus-shoot-extract-emphasis-on-characterization-and-in-vitro-antibacterial-properties-for-acne-treatment/ |
| ISSN | 2539-6293 |
| Abstract | Acne vulgaris is characterized by the production of comedones, papules, pustules, nodules, and cysts due to pilosebaceous unit expansion and inflammation. The presence of bacteria and accompanying inflammation increase this process even more. This study aimed to assess the anti-acne effects of chitosan microparticles (CMPs) loaded with the methanol extract of Apus bamboo (Gigantochloa apus) shoots (CMPs/Ab). The morphology of the CMPs/Ab appears to be spherical, with a particle size of 838.9 ± 33.4 nm and a zeta potential of +29.06 ± 1.22 mV, suggesting that the particles are micro-sized and stable. Moreover, the formulation of CMPs/Ab has an encapsulation effectiveness of 46.4 ± 0.91%. The antibacterial property of CMPs/Ab inhibits the growth of pathogenic bacteria caused by acne vulgaris, with an average inhibition zone of 41.67 ± 1.53 mm, 42.67 ± 2.52 mm, and 22.33 ± 1.53 mm for Staphylococcus aureus, S. epidermidis, and Cutibacterium acne, respectively. The CMPs/Abs formulated into anti-acne spray gel showed stable physical features for 28 days. It is a safe and potent anti-acne candidate that can disrupt the membranes of acne-causing bacteria, S. epidermidis, due to their natural composition, reducing the risk of adverse reactions and antibiotic resistance. |
