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In vitro antioxidant, alpha-glucosidase inhibition and antibacterial properties of Turbinaria decurrens Bory (Sargassaceae, Ochrophyta) |
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| รหัสดีโอไอ | |
| Creator | Eldrin Arguelles |
| Title | In vitro antioxidant, alpha-glucosidase inhibition and antibacterial properties of Turbinaria decurrens Bory (Sargassaceae, Ochrophyta) |
| Contributor | Eldrin Arguelles, Arsenia B. Sapin |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2563 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 25 |
| Journal No. | 3 |
| Page no. | 1-9 |
| Keyword | Algae, Bacterial pathogens, Bioactive compounds, Biological activity, Diabetes, Macroalgae, Philippines, Polyphenols, Phytochemicals, Seaweed, Turbinaria |
| URL Website | https://www.tci-thaijo.org/index.php/APST |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/240714/165247 |
| ISSN | 2539-6293 |
| Abstract | The genus Turbinaria is a chemically diverse group of seaweeds containing several phytochemicals with unique pharmacological activities useful in the treatment and management of diseases. This study was done to evaluate the bioactive potential of a brown macroalga, Turbinaria decurrens Bory from Pagkalitan, Batangas. The acidified methanolic extract of T. decurrens has a total phenolic content of 27.84 ฑ 0.12 mg gallic acid equivalents (GAE)/g. Antioxidant efficacy of T. decurrens exerted potent radical scavenging activity against 2-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and 2-diphenyl-1-picrylhydrazyl (DPPH) free radicals as well as high reducing capability of copper ions in a dose-dependent manner with half maximal inhibitory concentration (IC50) value of 49.31 ?g GAE/mL, 69.91 ?g GAE/mL and 17.2 ?g GAE/mL, respectively. In vitro study of ?-glucosidase inhibition showed that T. decurrens has potent inhibitory activity (IC50 of 11 ?g/mL) as compared to that of acarbose and metformin (anti-diabetic drugs) with IC50 values of 7960 ?g/mL and 49.66 mg/mL, respectively. Assessment of the antibacterial activities using microtiter plate dilution assay showed that T. decurrens have strong activity against Methicillin-resistant Staphylococcus aureus, minimum inhibitory concentration (MIC=125 ?g/mL) followed by Penicillin-acylase producing Bacillus cereus (MIC=250 ?g/mL), Staphylococcus epidermidis (MIC=250 ?g/mL), and Pseudomonas aeruginosa (MIC=500 ?g/mL). This investigation is one of the pioneering research studies in the Philippines showing the potential of T. decurrens extract as a cheap source of biologically active compounds with potential use for the treatment of drug-resistant bacterial infection and diabetes. |
