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Hibiscus sabdariffalinn. calyx extraction and gallic acid improving cardiac diastolic dysfunction in high fat diet-STZ-induced type 2 diabetic rats |
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| รหัสดีโอไอ | |
| Creator | Patchareewan Pannangpetch |
| Title | Hibiscus sabdariffalinn. calyx extraction and gallic acid improving cardiac diastolic dysfunction in high fat diet-STZ-induced type 2 diabetic rats |
| Contributor | Warintra Huaysrichan, Parichat Prachaney, Bunkerd Kongyingyoes, Upa Kukongviriyapan,Arunporn Itharat |
| Publisher | Research and Technology Transfer Affairs Division.Khon Kaen University. |
| Publication Year | 2560 |
| Journal Title | Asia-Pacific Journal of Science and Technology (APST) |
| Journal Vol. | 22 |
| Journal No. | 2 |
| Page no. | 1-9 |
| Keyword | Roselle, Hibiscus sabdariffa, Diabetic cardiomyopathy, Antioxidant |
| URL Website | https://tci-thaijo.org/index.php/APST/index |
| Website title | https://tci-thaijo.org/index.php/APST/article/view/84864 |
| ISSN | 2539-6293 |
| Abstract | Cardiovascular disease is one of serious complications of chronic diabetes. The objective of this study was to investigate the effects of HS-WE and gallic acid on ventricular function in high fat diet-streptozotocin (HFD-STZ)-induced Type 2 diabetic rats. Male Sprague-Dawley rats were used. The normal control group was fed normal rat chow. Diabetic groups were fed HFD for 4 weeks and followed by intraperitoneal injection of STZ 30 mg/kg. The diabetic rats were divided into 5 groups which were orally administered daily with distilled water, 50% propylene glycol, HS-WE (500 mg/kg), gallic acid (50 mg/kg), and metformin (200 mg/kg) for further 8 weeks. At the end of all treatments, the levels of fasting blood glucose (FBG), serum insulin, Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), plasma and heart malondialdehyde (MDA), heart superoxide production and left ventricular function were determined. Diabetic control rats showed significant increases in levels of FBG, HOMA-IR, MDA and superoxide production. In left ventricular function examination, an increase in diastolic ventricular pressure (DVP) and a decrease in (-)dP/dt were observed. HS-WE and gallic acid treated groups had significant decreases in FBG, HOMA-IR, plasma MDA, heart MDA and heart superoxide production as well as a decrease in DVP and an increase in (-)dP/dt when compared to diabetic control group. These results indicated that HS-WE and gallic acid improve diabetic induced diastolic dysfunction and this effect may be mediated via their antioxidant activities. |
